Ozone Therapy Benefits: How It Supports Overall Health and Wellness

Joseph Lopez • October 22, 2025

Ozone therapy is a medical and wellness treatment that uses a carefully controlled oxygen-ozone mixture to enhance the body’s natural healing processes. By introducing ozone into the bloodstream or tissues, therapy improves tissue oxygenation, supports the immune system, and promotes overall wellness.



People increasingly turn to ozone therapy as a complementary approach to health, seeking natural ways to boost energy, reduce inflammation, and support their body’s ability to recover from illness or chronic conditions.

Key Health Benefits of Ozone Therapy

Improved Oxygenation

Ozone therapy increases the oxygen levels in the blood, enhancing tissue oxygenation. This supports mitochondrial function, cellular energy production, and overall vitality.



Better oxygen delivery aids bone healing, recovery from chronic wounds, and improved physical and mental performance.

Immune System Support

Ozone therapy modulates the immune system by stimulating white blood cell activity and promoting the release of cytokines. Cytokines are signaling molecules that coordinate immune responses. 


Research shows ozone can enhance the activity of lymphocytes and macrophages, improving the body’s ability to respond to bacterial infections, viral infections, and other pathogens. 



By supporting immune regulation, this therapy may help reduce the frequency and severity of infections and improve resilience to illness.

Anti-Inflammatory Effects

Ozone activates antioxidant systems, helping reduce oxidative stress. This can support recovery from musculoskeletal conditions and aid chronic wound healing.



By modulating inflammatory pathways, ozone therapy helps reduce tissue damage and promotes overall cellular health. 

Detoxification and Cellular Health

Ozone therapy promotes detoxification by stimulating antioxidant enzyme systems, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, which neutralize reactive oxygen species. This helps reduce oxidative damage to DNA, proteins, and cell membranes. 


Ozone therapy may also support the removal of metabolic waste and toxins from the bloodstream, enhancing cellular repair and protecting senescent cells from further dysfunction. 



These effects contribute to healthier tissues and improved cellular resilience.

Energy and Metabolic Support

By enhancing oxygen utilization and supporting antioxidant systems, it metabolic processes, enhances the fatty acid cycle, and improves energy production.


Clinical observations suggest ozone therapy can improve mitochondrial efficiency, reduce fatigue, and enhance overall vitality. For individuals with chronic conditions, high-stress lifestyles, or reduced metabolic function, ozone therapy may help restore energy levels, support recovery from exertion, and maintain metabolic balance.

Applications of Ozone Therapy in Wellness

Ozone therapy is used in multiple areas of health and wellness:


  • Preventive health: Used as a proactive approach, ozone therapy may help maintain immune resilience and general vitality, supporting individuals who want to reduce susceptibility to common infections and oxidative stress.
  • Chronic conditions: Can assist in recovery from musculoskeletal conditions (issues related to muscles, bones, and connective tissues), fatigue, or chronic wounds.
  • Joint and musculoskeletal support: Treatments like intra-articular ozone injection and hyaluronic acid injections promote joint health and recovery.
  • Circulation and skin health: Improve blood circulation, which supports tissue nourishment and skin wellness. It is sometimes used to assist in recovery from minor injuries or to enhance skin quality in wellness-focused protocols.
  • Recovery and rejuvenation: Use of ozonated liquids and oxygen-ozone mixture therapy helps restore energy and reduce oxidative stress.


Its versatility makes ozone therapy a useful adjunct to conventional treatments, especially for those seeking non-invasive and natural approaches to wellness.

Safety and Considerations

When administered by trained professionals using proper medical equipment, ozone therapy is generally safe. Treatment plans are tailored to individual needs, ensuring that the dosage, method, and frequency are appropriate.


Mild side effects may include:



  • Fatigue or lightheadedness as the body adjusts to increased oxygen levels
  • Minor discomfort, redness, or a sensation at the injection or application site
  • Throat irritation or mild effects on the respiratory tract if ozone gas is inhaled


These effects are usually short-lived and resolve without intervention. 


Adverse effects are rare. Before having therapy, consult with a qualified medical provider. Especially for individuals with underlying medical conditions like  G-6PD deficiency or chronic lung diseases.  At Wellspring RH, clients receive a comprehensive assessment before therapy to review health status, discuss potential benefits, and tailor treatment protocols to maximize safety and effectiveness.

Integrating Ozone Therapy for Health and Wellness

Ozone therapy, including hyperbaric ozone therapy, topical ozonated oil, parenteral ozonated water, and oxygen-ozone gas, provides measurable benefits for overall wellness. Its effects on the immune system, oxidative stress, bone healing, chronic wound repair, and musculoskeletal conditions make it a valuable adjunct to conventional treatments.



With guidance from trained professionals, ozone therapy can be safely personalized, supporting preventive health, recovery, and long-term vitality.

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Oral Pills: Orally delivered hormones (pills) will pass through the liver prior to entering the bloodstream. This is called “first pass” metabolism. This has been shown to increase the risk of blood clotting and increased risk of heart attack and stroke, even if the hormone is bio-identical. In addition, when the liver metabolizes hormones it increases a protein called SHBG (sex hormone binding globulin) which binds up free testosterone and estrogen. This essentially makes the hormones given ineffective. Injectables: ‘Depot’ drug formulations are created by mixing a substance with the drug that slows its release and prolongs the action of the drug. The two most frequently used forms in the US are the testosterone esters, testosterone cypionate and testosterone enanthate which are almost interchangeable. These are only used in men as the doses would be too high for women. The adverse side effects of injected testosterone esters are generally associated with high peak levels in the first few days after an injection followed by lows after the injection starts to wear off. Some side effects may be lessened by using a shorter dosing interval (weekly or every ten days instead of twice monthly with enanthate or cypionate.) 100 mg weekly gives a much lower peak level of testosterone than does 200 mg every two weeks while still maintaining the same total dose of androgen. This benefit must be weighed against the discomfort and inconvenience of doubling the number of injections. Having “peaks and valleys” never allows the body to have sustained levels which would reset all the testosterone receptors causing the most positive effects on the body. Transdermal Therapy: The term “transdermal” refers to topical delivery through the skin, by the use of a gel, cream or patch. Transdermal hormones are usually applied to the skin in small daily doses in an effort to keep a steady level of hormones in the system at all times. This approach lessens the extreme “peaks and valleys” in hormone levels sometimes associated with injectable forms. With injectables, hormone levels rise dramatically initially and can reach a low-point a few days before the next shot is due, which can cause irritability, hot flashes, and low energy in some users. Transdermal application tends to be attractive to those individuals who are not comfortable with needles and injections. Even with once-daily use of gels and creams, you can also experience significant peaks and valleys which can cause adverse events. Some forms of daily transdermal application, particularly the patch, are substantially more expensive than injectable forms of hormones. Patches often cause skin irritation and/or allergic reactions to users. 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During the simple in-office procedure, the tiny pellets are inserted into the buttock area. The small incision site requires just a small bandage. The pellets which separately contain estradiol or testosterone (used individually or in combination), react to the needs of your body by secreting additional amounts of the hormones just as your body naturally would during periods of stress or exercise. Fortunately, the pellet therapy is consistently maintained, the body does not experience extreme highs and lows. Although many patients notice a difference within a few days, in particular estrogen effects, it can take up to four weeks or longer for the full effects to be felt. Which Is The Best Method Of Bio-Identical Hormone Therapy For Me? Today, bio-identical therapy is becoming mainstream and part of the age management movement. Many are looking to it not only for a way to help slow down aging and to deal with hormone imbalances. Ultimately, it is your decision to choose. 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